The Coccidioides antibody immunodiffsion test is used for the in vitro determination of precipitating antibodies to Coccidioides TP and F antigens. It is used as an aid in the diagnosis of Coccidioidomycosis.
The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.
– Negative serologic tests may be observed among culturally demonstrable cases, which limits the predictive value of a negative test.
– Negative serologic results obtained during the first month may warrant repeat testing.
– Falsely negative results may be obtained when testing immunocompromised patients.
– Test results cannot be used solely to distinguish between active infection and prior exposure.
Serum: Collect serum specimens in serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial.
Minimum Specimen Requirements
Serum: 0.25 mL per antibody
Positive samples will automatically reflex to a titer.
Refrigerated: 14 days
Frozen: 6 months
Any specimen types other than serum.
Ship on dry ice or frozen packs for next day service. Monday-Friday delivery.
Testing is performed on Tuesdays and Fridays.
Serum: 3 days from setup
– Antibody not detected
– Will report F and TP specific
Negative: Antibody not detected
Positive: Antibody detected, will report titer up to ≥1:128
– Antibodies to the TP antigen are typically detectable within 4 weeks of primary onset of infection but are rarely detected 6 months after infection. The presence of antibodies to the TP antigen may suggest recent or active infection.
– Antibodies to the F antigen are typically detectable by 6 weeks after the primary onset of the infection and may persist for several months to years.