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From the Desk of Dr. Wheat

Antibody Testing for Histoplasma and Blastomyces ─ What, When & Where?

Antibody Testing for Histoplasma and Blastomyces ─ What, When & Where?

At a Glance – Key Points 1. The MVista® Histoplasma and Blastomyces Antigen EIA tests are highly sensitive 2. There is high cross-reactivity between Histoplasma and Blastomyces antigen 3. Urine and serum antigen testing are neg in approximately 5% of cases 4. MVista® Histoplasma and Blastomyces IgG Antibody EIA tests are indicated if antigen testing...
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What Tests Should Be Performed for Diagnosing Coccidioidomycosis?

What Tests Should Be Performed for Diagnosing Coccidioidomycosis?

Drew Hanzlicek, DVM, MS, DACVIM (SAIM); Joe Wheat, MD; Heather Largura, DDS, MS Diagnosis. The most sensitive testing option for coccidioidomycosis is a combination of tests for antibodies including the MiraVista IgG EIA (MVista® Cocci IgG) and Immunodiffusion (Cocci ID). This combination provides a sensitivity of >98%, while still being highly specific (97%). An alternate...
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Invasive Fungal Infections NOT Invasive Diagnostic Investigations

Invasive Fungal Infections NOT Invasive Diagnostic Investigations

Histoplasma antigen detection is commonly used for diagnosis, treatment monitoring, and detection of disease relapse in veterinary medicine. The gold-standard for Histoplasma antigen detection is the MVista® Histoplasma Antigen Quantitative enzyme immunoassay (EIA). First made commercially available almost 20 years ago, it has been modified since to optimize diagnostic performance, turnaround time, and cost-efficiency. More...
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Invasive Fungal Infections NOT Invasive Diagnostic Investigations

Invasive Fungal Infections NOT Invasive Diagnostic Investigations

(1,3)-β-D-Glucan Antigen Test in Dogs and Cats By Drew Hanzlicek, DVM CLINICAL CHALLENGE Invasive fungal infections (IFI) often present a diagnostic challenge in dogs and cats. A few of the most notable include variable clinical presentations without pathognomonic clinical findings; disease in organ systems that require invasive procedures for sample collection; and slow fungal culture...
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Histoplasma Antigen Detection for Diagnosis of Histoplasmosis in Cats

Histoplasma Antigen Detection for Diagnosis of Histoplasmosis in Cats

Janelle Renschler, D.V.M., Ph.D., Dipl. ACVP and Joseph Wheat, MD Antigen detection for diagnosis of histoplasmosis in veterinary patients was first offered at MiraVista Diagnostics in 2004.  The MiraVista enzyme immunoassay (EIA) has been refined to improve sensitivity and permit quantification .  The MiraVista EIA has since become a leading method for diagnosis of progressive...
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Possibility of Fluconazole Resistance During Treatment for Histoplasmosis

Possibility of Fluconazole Resistance During Treatment for Histoplasmosis

Overview: Fluconazole is frequently used to treat cats with histoplasmosis, as it is well tolerated, cost effective, and available in convenient dosage form. In one study of 30 cats with histoplasmosis, treatment with fluconazole (19.3 mg/kg/day) led to similar survival and recrudescence rates as itraconazole (10.0 mg/kg/day), suggesting that fluconazole is an effective therapy for...
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Recommendation for the Most Effective Itraconazole Treatment of Serious Fungal Infections

Recommendation for the Most Effective Itraconazole Treatment of Serious Fungal Infections

FINDINGS FROM A RECENT CLINICAL STUDY PERFORMED AT MIRAVISTA DIAGNOSTICS
Improve Diagnosis of Coccidioidomycosis in Dogs with Combined Testing

Improve Diagnosis of Coccidioidomycosis in Dogs with Combined Testing

Coccidioidomycosis, a fungal infection endemic to the desert Southwestern United States, regions of South America, Central America, and Mexico is caused by the dimorphic fungi Coccidioides immitis and C. posadasii.  Dogs are typically exposed by inhalation of the spores from soil, and they often develop only subclinical or mild respiratory disease. In severe cases, dissemination...
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Antibody Testing Can Differentiate Histoplasmosis from Blastomycosis.

Antibody Testing Can Differentiate Histoplasmosis from Blastomycosis.

A 6-year-old Labrador retriever from Kentucky presented with sudden onset of coughing, lethargy and inappetence. Thoracic radiographs revealed diffuse nodular interstitial pulmonary infiltrates and tracheobronchial lymphadenopathy, suggestive of a systemic mycosis. The veterinarian submitted urine for both Blastomyces and Histoplasma antigen tests, with results of 4.5 ng/mL and 6.8 ng/mL, respectively. QUESTION: What diagnostic tests...
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