Cryptococcus Latex Agglutination

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  • Test Code


  • Clinical Significance

    -The Cryptococcus Antigen Latex Agglutination System is a qualitative and semi-quantitative test system for the detection of capsular polysaccharide antigens of Cryptococcus neoformans. Monitoring of the antigen titer may be useful during therapy, as clinical improvement is usually accompanied by a decrease in antigen titer.

    -Latex agglutination test has both diagnostic and prognostic value since progressive disease is usually accompanied by increasing antigen titers. Declining titers are usually associated with clinical improvement, with or without therapy. Inadequate therapy is indicated by stationary or rising titers on subsequent, sequential specimens. Cryptococcus antigen in the body fluids of the untreated patient indicates active infection. However, in some treated patients, titers remain positive at low levels for extended periods during which the organism can no longer be demonstrated.

  • Methodology

    -Latex Agglutination

    -Serum specimens are pre-treated with pronase and heat inactivated prior to testing.

    -CSF specimens are heat inactivated prior to testing.

  • Limitations

    The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions. Although the test sensitivity and specificity are high overall, false positives and false negatives may be observed. False negatives are more common with localized disease. Titers of up to 200 have been observed in cats without demonstrable overt cryptococcosis. High protein levels can cause interference.


  • Specimen Collection

    Serum: Collect serum specimens in serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial.

    CSF: Collect in sterile container. Centrifuge to remove leukocytes and particulate matter.

  • Minimum Specimen Requirements

    Serum/CSF: 0.25 mL

  • Specimen Stability

    RT: 7 days
    2 months

  • Specimen Rejection

    Serum types other than serum or CSF

  • Transport Temprature


  • Shipping

    Ship on dry ice or frozen packs for next day service. Monday – Friday delivery

  • Turnaround Time

    Testing is performed Monday-Friday.

    Serum/CSF: Same day

  • Reference Range

    None detected

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