Coccidioides Antibody Immunodiffusion
- Test Information
- Specimen Requirements
- Shipping Information
The Coccidioides Antibody Immunodiffusion test is used for the in vitro determination of precipitating antibodies to Coccidioides TP and F antigens. It is used as an aid in the diagnosis of Coccidioidomycosis.
The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.
- Negative serologic tests may be observed among culturally demonstrable cases, which limits the predictive value of a negative test.
- Negative serologic results obtained during the first month may warrant repeat testing.
- Falsely negative results may be obtained when testing immunocompromised patients.
- Test results cannot be used solely to distinguish between active infection and prior exposure.
Cross Reactivity/False Positive: Moderate to Low: Histoplasma, Blastomyces, and Aspergillus
Testing is performed Tuesday & Friday.
Results released: Positive: 24 hours; Negative: 72 hours
- Antibody not detected
- Will report F and TP specific
Negative: Antibody not detected
Positive: Antibody detected, will report titer up to ≥1:128
- Antibodies to the TP antigen are typically detectable within 4 weeks of primary onset of infection but are rarely detected 6 months after infection. The presence of antibodies to the TP antigen may suggest recent or active infection.
- Antibodies to the F antigen are typically detectable by 6 weeks after the primary onset of the infection and may persist for several months to years.
Specimen: Serum, CSF*, Plasma*
*Uncommon specimen includes incomplete validation. A ’rare specimen’ note will appear on the final report.
Serum: Collect serum specimens in serum separator tube. Allow blood to clot for 30 minutes, then centrifuge. Send serum in serum separator tube or transfer tube.
CSF, Plasma: Separator or transfer tube
Volume: 0.25 mL
Stability: Room temperature = 28 days, Refrigerated = 6 months, Frozen = indefinite
Any specimen types other than serum, CSF, plasma
Ship overnight with a cold pack.