Itraconazole Levels
- Test Information
- Specimen Requirements
- Shipping Information
Test Code
312
Clinical Significance
The MVista® Itraconazole bioassay test aids in monitoring antifungal therapy.
Methodology
Bioassay
Limitations
The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Interfering Substance:
- Other antifungals can cause falsely high results. Stop these at least 1 week before obtaining sample.
- Drug levels should be measured after steady-state (at least 2 weeks in dogs & 3 weeks in cats). It is recommended, but not required (due to long half-life), to collect blood sample at trough time (as close to next dose as possible).
Turnaround Time
Reported the following Thursday.
Reference Range
Recommended therapeutic range is 2.0 – 7.0 µg/mL
Interpretative Information
None Detected: Reported when there is no zone of inhibition.
<0.3 µg/mL: Reported when the zone of inhibition is smaller than that of the lowest calibrator.
Positive: 0.3 – 20.0 µg/mL
>20.0 µg/mL: Reported when the zone of inhibition is greater than the highest calibrator.Additional Information
- Follow-up testing may be necessary if there are changes in treatment, including starting or stopping interacting medications, or suspicion of treatment failure.
Drug levels should be measured after steady-state (at least 2 weeks in dogs & 3 weeks in cats). It is recommended, but not required (due to long half-life), to collect blood sample at trough time (as close to next dose as possible).
Specimen Collection
- Specimen: Serum
- Uncommon Specimen: CSF
Container:
- Serum: Submit serum in a separator or transfer tube.
- CSF: Submit CSF in a sterile leak-proof container.
Minimum Specimen Requirements
Volume: 0.25 mL
Specimen Stability
- Room temperature: 10 days
- Refrigerated: 10 days
- Frozen: indefinite
Specimen Rejection
Any specimen type other than serum.
Transport Temperature
Refrigerated/Frozen
Shipping
Ship overnight or 2nd day – with cold pack.
* New positives may require confirmation.
** Turnaround times are provided as ranges, and may vary depending on daily testing volumes and specimen type.
*** Test set up: Samples received by 10:30AM will have same-day test set up. Positive samples may require confirmation which may extend turnaround time. Serum & CSF specimens are pretreated to improve sensitivity which can add one day to turnaround time.