Coccidioides Antibody Immunodiffusion
- Test Information
- Specimen Requirements
- Shipping Information
Test Code
320
Clinical Significance
The Coccidioides Antibody Immunodiffusion test is used for the in vitro determination of precipitating antibodies to Coccidioides TP and F antigens. It is used as an aid in the diagnosis of Coccidioidomycosis.
Methodology
Fungal Immunodiffusion
Limitations
The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.
Cross Reactivity/False Positive: Moderate to Low: Histoplasma, Blastomyces, and Aspergillus
Turnaround Time
Results Released: 72 hours from set up
*New positives may require confirmationReference Range
- Antibody not detected
- Will report F and TP specific
Interpretative Information
Negative: Antibody not detected
Positive: Antibody detected, will report titer up to ≥1:128Additional Information
- Antibodies to the TP antigen are typically detectable within 4 weeks of primary onset of infection but are rarely detected 6 months after infection. The presence of antibodies to the TP antigen may suggest recent or active infection.
- Antibodies to the F antigen are typically detectable by 6 weeks after the primary onset of the infection and may persist for several months to years.
Specimen Collection
- Specimen: Serum
- Uncommon Specimen: CSF, Plasma
Container:
- Serum: Submit serum in a separator or transfer tube.
- CSF/Plasma: Submit CSF/Plasma in a sterile leak-proof container.
Minimum Specimen Requirements
Volume: 0.25 mL
Specimen Stability
- Room temperature: 28 days
- Refrigerated: 6 months
- Frozen: indefinite
Specimen Rejection
Any specimen types other than serum, CSF, plasma
Transport Temperature
Refrigerated/Frozen
Shipping
Ship overnight with a cold pack.
* New positives may require confirmation.
** Turnaround times are provided as ranges, and may vary depending on daily testing volumes and specimen type.
*** Test set up: Samples received by 10:30AM will have same-day test set up. Positive samples may require confirmation which may extend turnaround time. Serum & CSF specimens are pretreated to improve sensitivity which can add one day to turnaround time.