Increasing incidence of coccidioidomycosis and expansion north and east into new territories is documented in human medicine, but similar data is not readily available for animals. As it spreads geographically, it is important for those in non-endemic areas to recognize signs of infection. However, diagnosis of coccidioidomycosis is challenging because clinical presentation resembles other conditions, often delaying suspicion of fungal infection, diagnosis, and treatment. Early recognition and treatment improve outcomes. Read to learn more about current guidelines for coccidioidomycosis.