Aspergillus Galactomannan Antigen EIA

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  • Test Code

    309

  • Clinical Significance

    The Aspergillus antigen EIA test aids in the diagnosis of systemic aspergillosis in animals. This test has low sensitivity in dogs with sino-nasal aspergillosis; therefore, the test is not recommended for screening in those cases.

  • Methodology

    Platelia™ Aspergillus EIA immunoenzymatic sandwich microplate assay, cleared by the FDA for the detection of galactomannan in serum or BALF.

  • Limitations

    The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.

    • – Antifungal therapy may cause false negative results in patients with aspergillosis.
    • – Low positive results (0.5-1.5 GMI) are equivocal and may represent false positives, as the cutoff of 0.5 GMI was determined based on human studies for the early diagnosis of invasive fungal infections.
    • – False positives can be caused by:

    > Piperacillin-tazobactam, amoxicillin/clavulanic acid
    > PLASMA-LYTE and other fluids containing sodium gluconate
    > Infection with Penicillium, Alternaria, Paecilomyces, Fusarium, Histoplasma and Blastomyces, or airway colonization with above organisms

  • Specimen Collection
    • Serum: Collect serum specimens in serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial.
    • Urine/CSF/BAL: Submit CSF and BAL in a sterile screw cap container.
  • Minimum Specimen Requirements

    Serum/Urine/CSF/BAL: 0.8 mL

  • Specimen Stability
    • Room Temperature: 48 hours
    • Refrigerated: 5 days
    • Frozen: 5 months
  • Specimen Rejection

    If specimen is too viscous to pipette.

  • Transport Temprature

    Refrigerated/Frozen

  • Shipping

    Ship on dry ice or frozen packs for next day service. Monday-Friday delivery

  • Turnaround Time

    Serum/CSF/BAL: Same day

    *New positives may require confirmation

  • Reference Range

    Negative

  • Interpretative Information
    • Negative: <0.5

    *Results are reported as numeric values (Index) which are interpreted as positive or negative.

  • Additional Information

    Platelia™ is a registered trademark of BioRad.

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