Coccidioides Canine Antibody IgG EIA

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Test Code

329
Clinical Significance

The presence of IgG to Coccidioides assists in the diagnosis of coccidioidomycosis in dogs. IgG may be detected in some healthy dogs from the endemic area as a result of sub-clinical infection within the last 2 years. Intermediate results (8-9.9 EU) typically reflect either rising or falling IgG, and retesting the patient in several weeks may be beneficial.
Methodology

Semi-Quantitative Indirect Enzyme Immunoassay (EIA)
Limitations
- 6.4% cross reactivity with Blastomycosis
- 7.7% cross reactivity with Histoplasmosis
The reference range and other method performance specifications have not been established for this test in CSF. The test results should be integrated into the clinical context for interpretation.
Specimen Collection

Serum: Collect serum specimens in a serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial for shipment, is preferred. If plastic screw cap vial is not available, ship in specimen collection tube.

CSF: Sterile transport tube
Minimum Specimen Requirements

Serum: 0.25 mL
Specimen Stability
- Refrigerated: 14 days
- Frozen: 14 days
Specimen Rejection

Any specimen types other than serum or cerebrospinal fluid or if specimen exceeds stated stability ranges.
Transport Temprature

Refrigerated/Frozen
Shipping

Ship on dry ice for Monday – Friday, next day delivery. Frozen ice packs may be substituted if specimen is shipped the day of collection.
Turnaround Time

Testing is performed on Mondays and Thursdays.

Serum/CSF: Next Day
Reference Range

Negative
Interpretative Information
- Negative: <8.0 EU
- Intermediate: 8.0 – 9.9 EU
- Positive: 10.0 – ≥80.0 EU