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Coccidioides Antibody Immunodiffusion

  • Test Information
  • Specimen Requirements
  • Shipping Information

  • Test Code+-

    320

    Clinical Significance+-

    The Coccidioides Antibody Immunodiffusion test is used for the in vitro determination of precipitating antibodies to Coccidioides TP and F antigens. It is used as an aid in the diagnosis of Coccidioidomycosis.

    Methodology+-

    Fungal Immunodiffusion

    Limitations+-

    The result is not intended to be used as the sole means for clinical diagnosis or patient management decisions.

    • Negative serologic tests may be observed among culturally demonstrable cases, which limits the predictive value of a negative test.
    • Negative serologic results obtained during the first month may warrant repeat testing.
    • Falsely negative results may be obtained when testing immunocompromised patients.
    • Test results cannot be used solely to distinguish between active infection and prior exposure.

    Cross Reactivity/False Positive: Moderate to Low: Histoplasma, Blastomyces, and Aspergillus

    Turnaround Time+-

    Testing is performed Tuesday & Friday.

    Results released: Positive: 24 hours; Negative: 72 hours

    Reference Range+-

    • Antibody not detected
    • Will report F and TP specific

    Interpretative Information+-

    Negative: Antibody not detected
    Positive: Antibody detected, will report titer up to ≥1:128

    Additional Information+-

    • Antibodies to the TP antigen are typically detectable within 4 weeks of primary onset of infection but are rarely detected 6 months after infection. The presence of antibodies to the TP antigen may suggest recent or active infection.
    • Antibodies to the F antigen are typically detectable by 6 weeks after the primary onset of the infection and may persist for several months to years.

  • Specimen Collection+-

    Specimen:  Serum, CSF*, Plasma*
    *Uncommon specimen includes incomplete validation. A ’rare specimen’ note will appear on the final report.

    Container:
    Serum: Collect serum specimens in serum separator tube. Allow blood to clot for 30 minutes, then centrifuge. Send serum in serum separator tube or transfer tube.
    CSF, Plasma: Separator or transfer tube
    Volume:  0.25 mL
    Stability:  Room temperature = 28 days, Refrigerated = 6 months, Frozen = indefinite

    Specimen Rejection+-

    Any specimen types other than serum, CSF, plasma

  • Transport Temperature+-

    Refrigerated/Frozen

    Shipping+-

    Ship overnight with a cold pack.

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CREDENTIALS: