Histoplasma Feline Antibody IgG EIA

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  • Test Code

    328

  • Clinical Significance

    IgG antibodies to Histoplasma antigen appear to be associated with active infection, especially in cats with moderate to high positive (20 EU or greater) results. Antibodies may also be detected in a small percentage of healthy cats from the endemic area as a result of sub-clinical infection within the last 2 years.  IgG may be detected in histoplasmosis cases with falsely-negative antigen results (especially with localized disease or chronic infection) and combined antibody and antigen testing increases the overall sensitivity.  Intermediate results (8-9.9 EU) typically reflect either rising or falling IgG, and retesting the patient in several weeks may be beneficial.

  • Methodology

    Semi-Quantitative Indirect Enzyme Immunoassay (EIA)

  • Limitations

    ~1/3 of patients with Blastomycosis or Coccidioidomycosis will exhibit cross reactivity.

    The reference range and other method performance specifications have not been established for this test in CSF. The test results should be integrated into the clinical context for interpretation.

  • Specimen Collection

    Serum: Collect serum specimens in a serum separator or red top tube. Allow blood to clot for 30 minutes, then centrifuge. Pipette serum into a plastic screw cap vial for shipment, is preferred. If plastic screw cap vial is not available, ship in specimen collection tube.

    CSF: Sterile transport tube

  • Minimum Specimen Requirements

    Serum: 0.25 mL

  • Specimen Stability
    • Refrigerated: 14 days
    • Frozen: 14 days
  • Specimen Rejection

    >14 days old

    • – Any specimen types other than serum or cerebral spinal fluid.
    • – For specimen submissions that do not meet these criteria, please call Customer Service.
  • Transport Temprature

    Refrigerated/Frozen

  • Shipping

    Ship on dry ice for Monday – Friday, next day delivery. Frozen ice packs may be substituted if specimen is shipped the day of collection.

  • Turnaround Time

    Testing is performed on Mondays and Thursdays.

    Serum or CSF: Next Day

  • Reference Range

    Negative

  • Interpretative Information
    • Negative: <8.0 EU
    • Intermediate: 8.0 EU-9.9 EU
    • Positive: 10.0 EU-80.0 EU
    • Positive Above the Limit of Quantification: >80.0 EU
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CREDENTIALS:
CREDENTIALS: